Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.

Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.

The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract affo...

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Bibliographic Details
Main Authors: Ragasa, Consolacion Y., Ng, Vincent Antonio S., De Los Reyes, Mariquit M., Mandia, Emelina H., Oyong, Glenn G., Shen, Chien Chang
Format: text
Published: Animo Repository 2014
Subjects:
Meliaceae > Analysis
Meliaceae—Toxicity testing
Foliar diagnosis
Chemistry
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/1778
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Institution: De La Salle University
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Summary:The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract afforded squalene (1), β-sitosterol (2), polyprenols (3) and triglyceride (4). The structures of 1-4 were identified by comparison of their 1H NMR data with those reported in the literature. These compounds are known cytotoxic and anticancer compounds.

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