Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.

Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.

The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract affo...

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Main Authors: Ragasa, Consolacion Y., Ng, Vincent Antonio S., De Los Reyes, Mariquit M., Mandia, Emelina H., Oyong, Glenn G., Shen, Chien Chang
Format: text
Published: Animo Repository 2014
Subjects:
Meliaceae > Analysis
Meliaceae—Toxicity testing
Foliar diagnosis
Chemistry
Online Access:https://animorepository.dlsu.edu.ph/faculty_research/1778
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Institution: De La Salle University
id oai:animorepository.dlsu.edu.ph:faculty_research-2777
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spelling oai:animorepository.dlsu.edu.ph:faculty_research-27772021-07-25T22:04:23Z Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq. Ragasa, Consolacion Y. Ng, Vincent Antonio S. De Los Reyes, Mariquit M. Mandia, Emelina H. Oyong, Glenn G. Shen, Chien Chang The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract afforded squalene (1), β-sitosterol (2), polyprenols (3) and triglyceride (4). The structures of 1-4 were identified by comparison of their 1H NMR data with those reported in the literature. These compounds are known cytotoxic and anticancer compounds. 2014-01-01T08:00:00Z text https://animorepository.dlsu.edu.ph/faculty_research/1778 Faculty Research Work Animo Repository Meliaceae--Analysis Meliaceae—Toxicity testing Foliar diagnosis Chemistry
institution De La Salle University
building De La Salle University Library
continent Asia
country Philippines
Philippines
content_provider De La Salle University Library
collection DLSU Institutional Repository
topic Meliaceae--Analysis
Meliaceae—Toxicity testing
Foliar diagnosis
Chemistry
spellingShingle Meliaceae--Analysis
Meliaceae—Toxicity testing
Foliar diagnosis
Chemistry
Ragasa, Consolacion Y.
Ng, Vincent Antonio S.
De Los Reyes, Mariquit M.
Mandia, Emelina H.
Oyong, Glenn G.
Shen, Chien Chang
Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.
description The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract afforded squalene (1), β-sitosterol (2), polyprenols (3) and triglyceride (4). The structures of 1-4 were identified by comparison of their 1H NMR data with those reported in the literature. These compounds are known cytotoxic and anticancer compounds.
format text
author Ragasa, Consolacion Y.
Ng, Vincent Antonio S.
De Los Reyes, Mariquit M.
Mandia, Emelina H.
Oyong, Glenn G.
Shen, Chien Chang
author_facet Ragasa, Consolacion Y.
Ng, Vincent Antonio S.
De Los Reyes, Mariquit M.
Mandia, Emelina H.
Oyong, Glenn G.
Shen, Chien Chang
author_sort Ragasa, Consolacion Y.
title Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.
title_short Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.
title_full Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.
title_fullStr Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.
title_full_unstemmed Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.
title_sort chemical constituents and cytotoxicity of the leaves of dysoxylum gaudichaudianum (a. juss.) miq.
publisher Animo Repository
publishDate 2014
url https://animorepository.dlsu.edu.ph/faculty_research/1778
_version_ 1707058931415646208

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