Direct and stereospecific interaction of amphidinol 3 with sterol in lipid bilayers

• Main Authors: Espiritu, Rafael Atillo, Matsumori, Nobuaki, Tsuda, Masashi, Murata, Michio
• Format: text
• Published: Animo Repository 2014
• Subjects: Dinoflagellates; Antifungal agents; Sterols; Chemical reactions; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5119
• Institution: De La Salle University

Amphidinol 3 (AM3), a polyhydroxy-polyene metabolite from the dinoflagellate Amphidinium klebsii, possesses potent antifungal activity. Although AM3 permeabilizes phospholipid membranes only in the presence of sterol, the detailed molecular basis by which AM3 recognizes sterols in membranes remains...