Mechanism of action of membrane-active marine natural product theonellamide A

• Main Authors: Espiritu, Rafael Atillo, Matsumori, Nobuaki, Kinoshita, Masanao, Murata, Michio, Nishimura, Shinichi, Kakeya, Hideaki, Matsunaga, Shigeki, Yoshida, Minoru
• Format: text
• Published: Animo Repository 2013
• Subjects: Sponges—Composition; Membranes (Biology); Surface plasmon resonance; Nuclear magnetic resonance; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5115
• Institution: De La Salle University

Theonellamides (TNMs) are members of a distinctive family of antifungal and cytotoxic bicyclic dodecapeptides isolated from the marine sponge Theonella sp. Recently, it was shown that TNMs recognize 3β-hydroxysterol-containing membranes, induce glucan overproduction, and damage cellular membranes. H...