Accurate DNA fragment sizing by capillary electrophoresis with laser-induced fluorescence array for detection of sequence specificity of DNA damage

• Main Authors: Fundador, Erwin Oliver V., Choudhary, Dharamainder, Schenkman, John B., Rusling, James F.
• Format: text
• Published: Animo Repository 2008
• Subjects: Capillary electrophoresis; Laser-induced fluorescence; DNA damage; Biochemistry; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/5578
• Institution: De La Salle University

Cancer has been linked to mutations within specific codons in genes that code for critical biomolecules such as tumor suppressor proteins (e.g., p53). Activated metabolites like benzo[a]pyrenediol epoxide act on preferred nucleotide sequences of DNA, and such mutations have been identified in cancer...