Multi-compartmental modeling of APP processing influenced by SORLA in Alzheimer’s disease

• Main Authors: Lao, Angelyn R., Schmidt, Vanessa, Schmitz, Yvonne, Willnow, Thomas E., Wolkenhauer, Olaf
• Format: text
• Published: Animo Repository 2012
• Subjects: Amyloid beta-protein precursor—Mathematical models; Alzheimer's disease; Mathematics
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/7525
• Institution: De La Salle University

The formation of Aβ plaques from the processing of amyloid precursor protein (APP) is central to the pathology of Alzheimer's disease. Studies concerning APP processing are conventionally conducted in a single compartment where the reactants involved are either in a monomeric or a dimeric form...