Widespread recognition of 5' splice sites by noncanonical base-pairing to U1 snRNA involving bulged nucleotides

An established paradigm in pre-mRNA splicing is the recognition of the 5′ splice site (5′ss) by canonical base-pairing to the 5′ end of U1 small nuclear RNA (snRNA). We recently reported that a small subset of 5′ss base-pair to U1 in an alternate register that is shifted by 1 nucleotide. Using genet...

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Main Authors: Bennett, C. Frank, Roca, Xavier, Akerman, Martin, Gaus, Hans, Berdeja, Andrés, Krainer, Adrian R.
其他作者: School of Biological Sciences
格式: Article
語言:English
出版: 2013
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在線閱讀:https://hdl.handle.net/10356/100017
http://hdl.handle.net/10220/16284
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