Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses

• Main Authors: Kim, Jinsook, Lee, Soojung, Tsuda, Sachiko, Zhang, Xuying, Asrican, Brent, Gloss, Bernd, Feng, Guoping, Augustine, George James
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/100031; http://hdl.handle.net/10220/19679
• Institution: Nanyang Technological University

We used high-speed optogenetic mapping technology to examine the spatial organization of local inhibitory circuits formed by cerebellar interneurons. Transgenic mice expressing channelrhodopsin-2 exclusively in molecular layer interneurons allowed us to focally photostimulate these neurons, while me...