In vitro selection of mutant HDM2 resistant to nutlin inhibition

In vitro selection of mutant HDM2 resistant to nutlin inhibition

HDM2 binds to the p53 tumour suppressor and targets it for proteosomal degradation. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2 and abrogates its repressive function. Using a novel in vitro selection methodology, we simulated the emergence of resistance by...

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Bibliographic Details
Main Authors: Wei, Siau Jia., Joseph, Thomas., Sim, Adelene Y. L., Yurlova, Larisa., Zolghadr, Kourosh., Lane, David., Verma, Chandra., Ghadessy, Farid.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/100150
http://hdl.handle.net/10220/18644
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062564
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Institution: Nanyang Technological University
Language: English

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https://hdl.handle.net/10356/100150
http://hdl.handle.net/10220/18644
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062564

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