In vitro selection of mutant HDM2 resistant to nutlin inhibition
HDM2 binds to the p53 tumour suppressor and targets it for proteosomal degradation. Presently in clinical trials, the small molecule Nutlin-3A competitively binds to HDM2 and abrogates its repressive function. Using a novel in vitro selection methodology, we simulated the emergence of resistance by...
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Main Authors: | Wei, Siau Jia., Joseph, Thomas., Sim, Adelene Y. L., Yurlova, Larisa., Zolghadr, Kourosh., Lane, David., Verma, Chandra., Ghadessy, Farid. |
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Other Authors: | School of Biological Sciences |
Format: | Article |
Language: | English |
Published: |
2014
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/100150 http://hdl.handle.net/10220/18644 http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0062564 |
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Institution: | Nanyang Technological University |
Language: | English |
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