Structural insights into the dual-targeting mechanism of Nutlin-3

Structural insights into the dual-targeting mechanism of Nutlin-3

Multi-targeting therapy is an emerging strategy of drug discovery to improve therapeutic efficacy, safety and resistance profiles. In this study, we monitored the binding of a potent MDM2 inhibitor Nutlin-3 with anti-apoptotic Bcl-2 family proteins using NMR spectroscopy. Our results showed the univ...

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Bibliographic Details
Main Authors: Shin, Jae-Sun, Ha, Ji-Hyang, He, Fahu, Muto, Yutaka, Ryu, Kyoung-Seok, Yoon, Ho Sup, Kang, Sunghyun, Park, Sung Goo, Park, Byoung Chul, Choi, Sang-Un, Chi, Seung-Wook
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/99837
http://hdl.handle.net/10220/11029
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/99837
http://hdl.handle.net/10220/11029

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