Structural insights into the dual-targeting mechanism of Nutlin-3

• Main Authors: Shin, Jae-Sun, Ha, Ji-Hyang, He, Fahu, Muto, Yutaka, Ryu, Kyoung-Seok, Yoon, Ho Sup, Kang, Sunghyun, Park, Sung Goo, Park, Byoung Chul, Choi, Sang-Un, Chi, Seung-Wook
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/99837; http://hdl.handle.net/10220/11029
• Institution: Nanyang Technological University

Multi-targeting therapy is an emerging strategy of drug discovery to improve therapeutic efficacy, safety and resistance profiles. In this study, we monitored the binding of a potent MDM2 inhibitor Nutlin-3 with anti-apoptotic Bcl-2 family proteins using NMR spectroscopy. Our results showed the univ...