2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers....
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| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/100865 http://hdl.handle.net/10220/11049 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2′-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology. |
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