2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes

2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes

Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers....

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Main Authors: Lech, Christopher Jacques, Li, Zhe, Heddi, Brahim, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/100865
http://hdl.handle.net/10220/11049
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1008652020-03-07T12:34:50Z 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes Lech, Christopher Jacques Li, Zhe Heddi, Brahim Phan, Anh Tuân School of Physical and Mathematical Sciences Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2′-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology. 2013-07-09T03:33:04Z 2019-12-06T20:29:30Z 2013-07-09T03:33:04Z 2019-12-06T20:29:30Z 2012 2012 Journal Article Lech, C. J., Li, Z., Heddi, B., & Phan, A. T. (2012). 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes. Chemical Communications, 48, 11425-11427. https://hdl.handle.net/10356/100865 http://hdl.handle.net/10220/11049 10.1039/c2cc35097a en Chemical communications © 2012 The Royal Society of Chemistry.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description Here we demonstrate the applicability of 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for manipulating G-quadruplex folding by anti-position-favoring substitutions. A single guanine to 2′-F-ANA-guanine substitution can favor a single (3+1) hybrid conformation from a mixture of conformers. Rational substitutions of either type of 2′-F-modified nucleotide enable conformational switching from a (3+1) hybrid to a parallel folding topology.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Lech, Christopher Jacques
Li, Zhe
Heddi, Brahim
Phan, Anh Tuân
format Article
author Lech, Christopher Jacques
Li, Zhe
Heddi, Brahim
Phan, Anh Tuân
spellingShingle Lech, Christopher Jacques
Li, Zhe
Heddi, Brahim
Phan, Anh Tuân
2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
author_sort Lech, Christopher Jacques
title 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
title_short 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
title_full 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
title_fullStr 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
title_full_unstemmed 2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes
title_sort 2′-f-ana-guanosine and 2′-f-guanosine as powerful tools for structural manipulation of g-quadruplexes
publishDate 2013
url https://hdl.handle.net/10356/100865
http://hdl.handle.net/10220/11049
_version_ 1681047324065792000

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