TherMos : estimating protein-DNA binding energies from in vivo binding profiles

• Main Authors: Sun, Wenjie, Hu, Xiaoming, Choo, Siew Hua, Drechsel, Daniela, Guillemot, Franc, Jauch, Ralf, Prabhakar, Shyam, Lim, Michael H. K., Ng, Calista K. L., Castro, Diogo S., Kolatkar, Prasanna R.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/100914; http://hdl.handle.net/10220/18607
• Institution: Nanyang Technological University

Accurately characterizing transcription factor (TF)-DNA affinity is a central goal of regulatory genomics. Although thermodynamics provides the most natural language for describing the continuous range of TF-DNA affinity, traditional motif discovery algorithms focus instead on classification paradig...