Deciphering the Sox-Oct partner code by quantitative cooperativity measurements

• Main Authors: Prabhakar, Shyam, Jauch, Ralf, Ng, Calista K. L., Li, Noel X., Chee, Sheena., Kolatkar, Prasanna R.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101526; http://hdl.handle.net/10220/18725
• Institution: Nanyang Technological University

Several Sox-Oct transcription factor (TF) combinations have been shown to cooperate on diverse enhancers to determine cell fates. Here, we developed a method to quantify biochemically the Sox-Oct cooperation and assessed the pairing of the high-mobility group (HMG) domains of 11 Sox TFs with Oct4 on...