Deciphering the Sox-Oct partner code by quantitative cooperativity measurements

• المؤلفون الرئيسيون: Prabhakar, Shyam, Jauch, Ralf, Ng, Calista K. L., Li, Noel X., Chee, Sheena., Kolatkar, Prasanna R.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/101526; http://hdl.handle.net/10220/18725
• المؤسسة: Nanyang Technological University

Several Sox-Oct transcription factor (TF) combinations have been shown to cooperate on diverse enhancers to determine cell fates. Here, we developed a method to quantify biochemically the Sox-Oct cooperation and assessed the pairing of the high-mobility group (HMG) domains of 11 Sox TFs with Oct4 on...