Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)

Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)

A palladacycle-catalyzed diastereo- and enantioselective stepwise double hydrophosphination of bis(enones) with PhPH2 has been developed, allowing intermolecular construction of chiral tertiary bulky P-heterocycles in one pot in high yields. A catalytic cycle for the reaction is proposed as well.

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Bibliographic Details
Main Authors: Pullarkat, Sumod A., Huang, Yinhua, Teong, Siewping, Chew, Renta Jonathan, Li, Yongxin, Leung, Pak-Hing
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/101232
http://hdl.handle.net/10220/13697
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Institution: Nanyang Technological University
Language: English
Description
Summary:A palladacycle-catalyzed diastereo- and enantioselective stepwise double hydrophosphination of bis(enones) with PhPH2 has been developed, allowing intermolecular construction of chiral tertiary bulky P-heterocycles in one pot in high yields. A catalytic cycle for the reaction is proposed as well.

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