Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)

Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)

A palladacycle-catalyzed diastereo- and enantioselective stepwise double hydrophosphination of bis(enones) with PhPH2 has been developed, allowing intermolecular construction of chiral tertiary bulky P-heterocycles in one pot in high yields. A catalytic cycle for the reaction is proposed as well.

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Main Authors: Pullarkat, Sumod A., Huang, Yinhua, Teong, Siewping, Chew, Renta Jonathan, Li, Yongxin, Leung, Pak-Hing
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/101232
http://hdl.handle.net/10220/13697
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1012322020-03-07T12:37:08Z Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones) Pullarkat, Sumod A. Huang, Yinhua Teong, Siewping Chew, Renta Jonathan Li, Yongxin Leung, Pak-Hing School of Physical and Mathematical Sciences A palladacycle-catalyzed diastereo- and enantioselective stepwise double hydrophosphination of bis(enones) with PhPH2 has been developed, allowing intermolecular construction of chiral tertiary bulky P-heterocycles in one pot in high yields. A catalytic cycle for the reaction is proposed as well. 2013-09-25T07:47:04Z 2019-12-06T20:35:26Z 2013-09-25T07:47:04Z 2019-12-06T20:35:26Z 2012 2012 Journal Article Huang, Y., Pullarkat, S. A., Teong, S., Chew, R. J., Li, Y., & Leung, P.-H. (2012). Palladacycle-Catalyzed Asymmetric Intermolecular Construction of Chiral Tertiary P-Heterocycles by Stepwise Addition of H–P–H Bonds to Bis(enones). Organometallics, 31(13), 4871–4875. https://hdl.handle.net/10356/101232 http://hdl.handle.net/10220/13697 10.1021/om300405h en Organometallics
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
description A palladacycle-catalyzed diastereo- and enantioselective stepwise double hydrophosphination of bis(enones) with PhPH2 has been developed, allowing intermolecular construction of chiral tertiary bulky P-heterocycles in one pot in high yields. A catalytic cycle for the reaction is proposed as well.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Pullarkat, Sumod A.
Huang, Yinhua
Teong, Siewping
Chew, Renta Jonathan
Li, Yongxin
Leung, Pak-Hing
format Article
author Pullarkat, Sumod A.
Huang, Yinhua
Teong, Siewping
Chew, Renta Jonathan
Li, Yongxin
Leung, Pak-Hing
spellingShingle Pullarkat, Sumod A.
Huang, Yinhua
Teong, Siewping
Chew, Renta Jonathan
Li, Yongxin
Leung, Pak-Hing
Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
author_sort Pullarkat, Sumod A.
title Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
title_short Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
title_full Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
title_fullStr Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
title_full_unstemmed Palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of H–P–H bonds to bis(enones)
title_sort palladacycle-catalyzed asymmetric intermolecular construction of chiral tertiary p-heterocycles by stepwise addition of h–p–h bonds to bis(enones)
publishDate 2013
url https://hdl.handle.net/10356/101232
http://hdl.handle.net/10220/13697
_version_ 1681039006186340352

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