Nanobody mediated crystallization of an archeal mechanosensitive channel

• Main Authors: Moberg, Per, Quistgaard, Esben M., Löw, Christian, Yau, Yin Hoe, Pardon, Els, Jegerschöld, Caroline, Wåhlin, Lisa, Geifman-Shochat, Susana, Steyaert, Jan, Nordlund, Pär
• Other Authors: Dryer, Stuart E.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101386; http://hdl.handle.net/10220/18395
• Institution: Nanyang Technological University

Mechanosensitive channels (MS) are integral membrane proteins and allow bacteria to survive sudden changes in external osmolarity due to transient opening of their pores. The efflux of cytoplasmic osmolytes reduces the membrane tension and prevents membrane rupture. Therefore these channels serve as...