Structural analysis on mutation residues and interfacial water molecules for human TIM disease understanding

• Main Authors: Li, Zhenhua, He, Ying, Liu, Qian, Zhao, Liang, Wong, Limsoon, Kwoh, Chee Keong, Nguyen, Hung, Li, Jinyan
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Computer science and engineering::Computer applications::Life and medical sciences
• Online Access: https://hdl.handle.net/10356/101425; http://hdl.handle.net/10220/18404
• Institution: Nanyang Technological University

Background: Human triosephosphate isomerase (HsTIM) deficiency is a genetic disease caused often by the pathogenic mutation E104D. This mutation, located at the side of an abnormally large cluster of water in the inter-subunit interface, reduces the thermostability of the enzyme. Why and how these w...