Single vesicle analysis reveals nanoscale membrane curvature selective pore formation in lipid membranes by an antiviral α-helical peptide

• Main Authors: Zhdanov, Vladimir P., Tabaei, Seyed R., Rabe, Michael, Cho, Nam-Joon, Höök, Fredrik
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/101429; http://hdl.handle.net/10220/11090
• Institution: Nanyang Technological University

Using tethered sub-100 nm lipid vesicles that mimic enveloped viruses with nanoscale membrane curvature, we have in this work designed a total internal reflection fluorescence microscopy-based single vesicle assay to investigate how an antiviral amphipathic α-helical (AH) peptide interacts with lipi...