Pick one, but be quick : 5' splice sites and the problems of too many choices

• Main Authors: Roca, Xavier, Krainer, Adrian R., Eperon, Ian C.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101529; http://hdl.handle.net/10220/18670
• Institution: Nanyang Technological University

Splice site selection is fundamental to pre-mRNA splicing and the expansion of genomic coding potential. 5′ Splice sites (5′ss) are the critical elements at the 5′ end of introns and are extremely diverse, as thousands of different sequences act as bona fide 5′ss in the human transcriptome. Most 5′s...