X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis

• Main Authors: Jain, Neeraj, Tan, Jun Hou, Feng, Shijin, George, Bhawana, Thanabalu, Thirumaran
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/101933; http://hdl.handle.net/10220/24212
• Institution: Nanyang Technological University

Background: Mutation in the Wiskott-Aldrich syndrome Protein (WASP) causes Wiskott-Aldrich syndrome (WAS), X-linked thrombocytopenia (XLT) and X-linked congenital neutropenia (XLN). The majority of missense mutations causing WAS and XLT are found in the WH1 (WASP Homology) domain of WASP, known to m...