Bicyclic-guanidine-catalyzed asymmetric Michael addition of 3-substituted oxindoles to 2-cyclopentenone
Taking the Michael: The first highly enantio- and diastereoselective Michael addition of various 3-benzyl-substituted oxindoles to 2-cyclopentenone has been developed. A variety of 3,3-disubstituted oxindoles as Michael adducts were obtained in 69–99 % yield with 73–98 % ee and 9:1 to >20:1 d.r....
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| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/102113 http://hdl.handle.net/10220/18901 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | Taking the Michael: The first highly enantio- and diastereoselective Michael addition of various 3-benzyl-substituted oxindoles to 2-cyclopentenone has been developed. A variety of 3,3-disubstituted oxindoles as Michael adducts were obtained in 69–99 % yield with 73–98 % ee and 9:1 to >20:1 d.r. |
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