Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming

• Main Authors: Aksoy, Irene, Jauch, Ralf, Eras, Volker, Chng, Wen-bin Alfred, Chen, Jiaxuan, Divakar, Ushashree, Ng, Calista Keow Leng, Kolatkar, Prasanna R., Stanton, Lawrence W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/102574; http://hdl.handle.net/10220/19110
• Institution: Nanyang Technological University

The unique ability of Sox2 to cooperate with Oct4 at selective binding sites in the genome is critical for reprogramming somatic cells into induced pluripotent stem cells (iPSCs). We have recently demonstrated that Sox17 can be converted into a reprogramming factor by alteration of a single amino ac...