Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery

• Main Authors: Zhang, Xiaoyu, Zhang, Haixia, Xu, Zhigang, Wang, Dongdong, Xu, Shuang, Liu, Xiaoyan
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Chemical engineering::Biochemical engineering
• Online Access: https://hdl.handle.net/10356/102820; http://hdl.handle.net/10220/19206
• Institution: Nanyang Technological University

We present here a novel camptothecin (CPT) prodrug based on polyethylene glycol monomethyl ether-block-poly(2-methacryl ester hydroxyethyl disulfide-graft-CPT) (MPEG-SS-PCPT). It formed biocompatible nanoparticles (NPs) with diameters of approximately 122 nm with a CPT loading content as high as app...