Growth inhibition of pathogenic bacteria by sulfonylurea herbicides

Growth inhibition of pathogenic bacteria by sulfonylurea herbicides

Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects...

Full description

Saved in:
Bibliographic Details
Main Authors: Krishna, Aishwarya, Joseph, Thomas L., Wang, Jing, Ong, Catherine, Ooi, Hui Ann, Kreisberg, Jason F., Ong, Nicholas T., Sung, Julie C., Siew, Chern Chiang, Chang, Grace C., Biot, Fabrice, Cuccui, Jon, Wren, Brendan W., Chan, Joey, Sivalingam, Suppiah P., Zhang, Lian-Hui, Verma, Chandra, Tan, Patrick
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Biological sciences::Microbiology::Bacteria
Online Access:https://hdl.handle.net/10356/102995
http://hdl.handle.net/10220/25811
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.

Similar Items