Growth inhibition of pathogenic bacteria by sulfonylurea herbicides

• Main Authors: Krishna, Aishwarya, Joseph, Thomas L., Wang, Jing, Ong, Catherine, Ooi, Hui Ann, Kreisberg, Jason F., Ong, Nicholas T., Sung, Julie C., Siew, Chern Chiang, Chang, Grace C., Biot, Fabrice, Cuccui, Jon, Wren, Brendan W., Chan, Joey, Sivalingam, Suppiah P., Zhang, Lian-Hui, Verma, Chandra, Tan, Patrick
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/102995; http://hdl.handle.net/10220/25811
• Institution: Nanyang Technological University

Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects...