Growth inhibition of pathogenic bacteria by sulfonylurea herbicides

Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects...

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Main Authors:	Krishna, Aishwarya, Joseph, Thomas L., Wang, Jing, Ong, Catherine, Ooi, Hui Ann, Kreisberg, Jason F., Ong, Nicholas T., Sung, Julie C., Siew, Chern Chiang, Chang, Grace C., Biot, Fabrice, Cuccui, Jon, Wren, Brendan W., Chan, Joey, Sivalingam, Suppiah P., Zhang, Lian-Hui, Verma, Chandra, Tan, Patrick
Other Authors:	School of Biological Sciences
Format:	Article
Language:	English
Published:	2015
Subjects:	DRNTU::Science::Biological sciences::Microbiology::Bacteria
Online Access:	https://hdl.handle.net/10356/102995 http://hdl.handle.net/10220/25811
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-102995
record_format	dspace
spelling	sg-ntu-dr.10356-1029952023-02-28T17:03:48Z Growth inhibition of pathogenic bacteria by sulfonylurea herbicides Krishna, Aishwarya Joseph, Thomas L. Wang, Jing Ong, Catherine Ooi, Hui Ann Kreisberg, Jason F. Ong, Nicholas T. Sung, Julie C. Siew, Chern Chiang Chang, Grace C. Biot, Fabrice Cuccui, Jon Wren, Brendan W. Chan, Joey Sivalingam, Suppiah P. Zhang, Lian-Hui Verma, Chandra Tan, Patrick School of Biological Sciences DRNTU::Science::Biological sciences::Microbiology::Bacteria Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy. Published version 2015-06-08T01:03:48Z 2019-12-06T21:03:33Z 2015-06-08T01:03:48Z 2019-12-06T21:03:33Z 2013 2013 Journal Article Kreisberg, J. F., Ong, N. T., Krishna, A., Joseph, T. L., Wang, J., Ong, C., et al. (2013). Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. Antimicrobial agents and chemotherapy, 57(3), 1513-1517. 0066-4804 https://hdl.handle.net/10356/102995 http://hdl.handle.net/10220/25811 10.1128/AAC.02327-12 23263008 en Antimicrobial agents and chemotherapy © 2013 American Society for Microbiology (ASM). This paper was published in Antimicrobial Agents and Chemotherapy and is made available as an electronic reprint (preprint) with permission of American Society for Microbiology (ASM). The paper can be found at the following official DOI: [http://dx.doi.org/10.1128/AAC.02327-12]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 5 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	DRNTU::Science::Biological sciences::Microbiology::Bacteria
spellingShingle	DRNTU::Science::Biological sciences::Microbiology::Bacteria Krishna, Aishwarya Joseph, Thomas L. Wang, Jing Ong, Catherine Ooi, Hui Ann Kreisberg, Jason F. Ong, Nicholas T. Sung, Julie C. Siew, Chern Chiang Chang, Grace C. Biot, Fabrice Cuccui, Jon Wren, Brendan W. Chan, Joey Sivalingam, Suppiah P. Zhang, Lian-Hui Verma, Chandra Tan, Patrick Growth inhibition of pathogenic bacteria by sulfonylurea herbicides
description	Emerging resistance to current antibiotics raises the need for new microbial drug targets. We show that targeting branched-chain amino acid (BCAA) biosynthesis using sulfonylurea herbicides, which inhibit the BCAA biosynthetic enzyme acetohydroxyacid synthase (AHAS), can exert bacteriostatic effects on several pathogenic bacteria, including Burkholderia pseudomallei, Pseudomonas aeruginosa, and Acinetobacter baumannii. Our results suggest that targeting biosynthetic enzymes like AHAS, which are lacking in humans, could represent a promising antimicrobial drug strategy.
author2	School of Biological Sciences
author_facet	School of Biological Sciences Krishna, Aishwarya Joseph, Thomas L. Wang, Jing Ong, Catherine Ooi, Hui Ann Kreisberg, Jason F. Ong, Nicholas T. Sung, Julie C. Siew, Chern Chiang Chang, Grace C. Biot, Fabrice Cuccui, Jon Wren, Brendan W. Chan, Joey Sivalingam, Suppiah P. Zhang, Lian-Hui Verma, Chandra Tan, Patrick
format	Article
author	Krishna, Aishwarya Joseph, Thomas L. Wang, Jing Ong, Catherine Ooi, Hui Ann Kreisberg, Jason F. Ong, Nicholas T. Sung, Julie C. Siew, Chern Chiang Chang, Grace C. Biot, Fabrice Cuccui, Jon Wren, Brendan W. Chan, Joey Sivalingam, Suppiah P. Zhang, Lian-Hui Verma, Chandra Tan, Patrick
author_sort	Krishna, Aishwarya
title	Growth inhibition of pathogenic bacteria by sulfonylurea herbicides
title_short	Growth inhibition of pathogenic bacteria by sulfonylurea herbicides
title_full	Growth inhibition of pathogenic bacteria by sulfonylurea herbicides
title_fullStr	Growth inhibition of pathogenic bacteria by sulfonylurea herbicides
title_full_unstemmed	Growth inhibition of pathogenic bacteria by sulfonylurea herbicides
title_sort	growth inhibition of pathogenic bacteria by sulfonylurea herbicides
publishDate	2015
url	https://hdl.handle.net/10356/102995 http://hdl.handle.net/10220/25811
_version_	1759855283924893696

Growth inhibition of pathogenic bacteria by sulfonylurea herbicides

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