A U⋅U pair-to-U.C pair mutation-induced RNA native structure destabilisation and stretching-force-induced RNA misfolding

• المؤلفون الرئيسيون: Zhong, Zhensheng, Soh, Lai Huat, Lim, Ming Hui, Chen, Gang
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Chemistry::Physical chemistry::Molecular structure and bonding
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/103029; http://hdl.handle.net/10220/25802

Little is known about how a non-Watson–Crick pair affects the RNA folding dynamics. We studied the effects of a U⋅U-to-U⋅C pair mutation on the folding of a hairpin in human telomerase RNA. The ensemble thermal melting of the hairpins shows an on-pathway intermediate with the disruption of the inter...