A U⋅U pair-to-U.C pair mutation-induced RNA native structure destabilisation and stretching-force-induced RNA misfolding

• Main Authors: Zhong, Zhensheng, Soh, Lai Huat, Lim, Ming Hui, Chen, Gang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Physical chemistry::Molecular structure and bonding
• Online Access: https://hdl.handle.net/10356/103029; http://hdl.handle.net/10220/25802
• Institution: Nanyang Technological University

Little is known about how a non-Watson–Crick pair affects the RNA folding dynamics. We studied the effects of a U⋅U-to-U⋅C pair mutation on the folding of a hairpin in human telomerase RNA. The ensemble thermal melting of the hairpins shows an on-pathway intermediate with the disruption of the inter...