Incorporating uracil and 5-halouracils into short peptide nucleic acids for enhanced recognition of A–U pairs in dsRNAs

• Main Authors: Patil, Kiran M., Ong, Alan Ann Lerk, Krishna, Manchugondanahalli Shivakumar, Toh, Desiree-Faye Kaixin, Yuan, Zhen, Meng, Zhenyu, Shu, Zhiyu, Zhang, Haiping, Lu, Lanyuan, Lu, Yunpeng, Chen, Gang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Biological sciences; Double-stranded RNA; Enhanced Recognition
• Online Access: https://hdl.handle.net/10356/103677; http://hdl.handle.net/10220/47378
• Institution: Nanyang Technological University

Double-stranded RNA (dsRNA) structures form triplexes and RNA-protein complexes through binding to single-stranded RNA (ssRNA) regions and proteins, respectively, for diverse biological functions. Hence, targeting dsRNAs through major-groove triplex formation is a promising strategy for the developm...