Recognition of RNA secondary structures with a programmable peptide nucleic acid-based platform

• Main Authors: Lu, Rongguang, Deng, Liping, Lian, Yun, Ke, Xin, Yang, Lixia, Xi, Kun, Ong, Alan Ann Lerk, Chen, Yanyu, Zhou, Hanting, Meng, Zhenyu, Lin, Ruiyu, Fan, Shijian, Liu, Yining, Toh, Desiree-Faye Kaixin, Zhan, Xuan, Krishna, Manchugondanahalli S., Patil, Kiran M., Lu, Yunpeng, Liu, Zheng, Zhu, Lizhe, Wang, Hongwei, Li, Guobao, Chen, Gang
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Double-stranded RNA; miRNA precursor
• Online Access: https://hdl.handle.net/10356/181785
• Institution: Nanyang Technological University

RNA secondary structures comprise double-stranded (ds) and single-stranded (ss) regions. Antisense peptide nucleic acids (asPNAs) enable the targeting of ssRNAs and weakly formed dsRNAs. Nucleobase-modified dsRNA-binding PNAs (dbPNAs) allow for dsRNA targeting. A programmable RNA-structure-specific...