Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids

Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids

The field of asymmetric (transfer) hydrogenation of prochiral olefins has been dominated by noble metal catalysts based on rhodium, ruthenium, and iridium. Herein we report that a simple nickel catalyst is highly active in the transfer hydrogenation using formic acid. Chiral α- and β-amino acid deri...

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Main Authors: Yang, Peng, Xu, Haiyan, Zhou, Jianrong Steve
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Chemistry::Physical chemistry::Catalysis
Online Access:https://hdl.handle.net/10356/103044
http://hdl.handle.net/10220/24444
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1030442020-03-07T12:34:44Z Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids Yang, Peng Xu, Haiyan Zhou, Jianrong Steve School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Physical chemistry::Catalysis The field of asymmetric (transfer) hydrogenation of prochiral olefins has been dominated by noble metal catalysts based on rhodium, ruthenium, and iridium. Herein we report that a simple nickel catalyst is highly active in the transfer hydrogenation using formic acid. Chiral α- and β-amino acid derivatives were obtained in good to excellent enantioselectivity. The key toward success was the use of the strongly donating and sterically demanding bisphosphine Binapine. 2014-12-11T08:43:48Z 2019-12-06T21:04:23Z 2014-12-11T08:43:48Z 2019-12-06T21:04:23Z 2014 2014 Journal Article Yang, P., Xu, H., & Zhou, J. S. (2014). Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids. Angewandte chemie international edition, 53(45), 12210-12213. 1433-7851 https://hdl.handle.net/10356/103044 http://hdl.handle.net/10220/24444 10.1002/anie.201407744 en Angewandte chemie international edition © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Physical chemistry::Catalysis
spellingShingle DRNTU::Science::Chemistry::Physical chemistry::Catalysis
Yang, Peng
Xu, Haiyan
Zhou, Jianrong Steve
Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids
description The field of asymmetric (transfer) hydrogenation of prochiral olefins has been dominated by noble metal catalysts based on rhodium, ruthenium, and iridium. Herein we report that a simple nickel catalyst is highly active in the transfer hydrogenation using formic acid. Chiral α- and β-amino acid derivatives were obtained in good to excellent enantioselectivity. The key toward success was the use of the strongly donating and sterically demanding bisphosphine Binapine.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Yang, Peng
Xu, Haiyan
Zhou, Jianrong Steve
format Article
author Yang, Peng
Xu, Haiyan
Zhou, Jianrong Steve
author_sort Yang, Peng
title Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids
title_short Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids
title_full Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids
title_fullStr Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids
title_full_unstemmed Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids
title_sort nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids
publishDate 2014
url https://hdl.handle.net/10356/103044
http://hdl.handle.net/10220/24444
_version_ 1681035648182517760

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