Nickel-catalyzed asymmetric transfer hydrogenation of olefins for the synthesis of α- and β-amino acids

• Main Authors: Yang, Peng, Xu, Haiyan, Zhou, Jianrong Steve
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Physical chemistry::Catalysis
• Online Access: https://hdl.handle.net/10356/103044; http://hdl.handle.net/10220/24444
• Institution: Nanyang Technological University

The field of asymmetric (transfer) hydrogenation of prochiral olefins has been dominated by noble metal catalysts based on rhodium, ruthenium, and iridium. Herein we report that a simple nickel catalyst is highly active in the transfer hydrogenation using formic acid. Chiral α- and β-amino acid deri...