Synthesis, optical resolution, and stereochemical properties of a rationally designed chiral C–N palladacycle

• Main Authors: Li, Yongxin, Pullarkat, Sumod A., Leung, Pak-Hing, Yap, Jeanette See Leng, Chen, Houguang Jeremy
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds
• Online Access: https://hdl.handle.net/10356/103110; http://hdl.handle.net/10220/24356
• Institution: Nanyang Technological University

A novel racemic tertiary amine, 1-(2,5-diisopropylphenyl)-N,N-dimethylethanamine, was synthesized from 2,5-diisopropylbenzaldehyde via a multistep approach in high overall yield. The ortho palladation of this ligand was found to be sensitive to the reaction conditions and the palladating reagents em...