Adaptation of pandemic H2N2 influenza A viruses in humans

Adaptation of pandemic H2N2 influenza A viruses in humans

The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we per...

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Bibliographic Details
Main Authors: Joseph, Udayan, Linster, Martin, Suzuki, Yuka, Krauss, Scott, Halpin, Rebecca A., Vijaykrishna, Dhanasekaran, Fabrizio, Thomas P., Bestebroer, Theo M., Maurer-Stroh, Sebastian, Webby, Richard J., Wentworth, David E., Fouchier, Ron A. M., Bahl, Justin, Smith, Gavin J. D.
Other Authors: Dermody, T. S.
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Biological sciences::Microbiology::Virology
Online Access:https://hdl.handle.net/10356/103217
http://hdl.handle.net/10220/25774
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Institution: Nanyang Technological University
Language: English
Description
Summary:The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we performed analyses on genetic sequences of 175 newly sequenced human and avian H2N2 virus isolates and all publicly available influenza virus genomes.

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