Adaptation of pandemic H2N2 influenza A viruses in humans

• Main Authors: Joseph, Udayan, Linster, Martin, Suzuki, Yuka, Krauss, Scott, Halpin, Rebecca A., Vijaykrishna, Dhanasekaran, Fabrizio, Thomas P., Bestebroer, Theo M., Maurer-Stroh, Sebastian, Webby, Richard J., Wentworth, David E., Fouchier, Ron A. M., Bahl, Justin, Smith, Gavin J. D.
• Other Authors: Dermody, T. S.
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Virology
• Online Access: https://hdl.handle.net/10356/103217; http://hdl.handle.net/10220/25774
• Institution: Nanyang Technological University

The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species and pigs, the threat of reintroduction into humans remains. To determine factors involved in the zoonotic origin of the 1957 pandemic, we per...