MicroRNAs : the next generation therapeutic targets in human diseases

MicroRNAs : the next generation therapeutic targets in human diseases

MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA- related genetic alter...

Full description

Saved in:
Bibliographic Details
Main Authors: Srinivasan, Sakthivel, Selvan, Subramanian Tamil, Archunan, Govindaraju, Gulyas, Balazs, Padmanabhan, Parasuraman
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Medicine
Online Access:https://hdl.handle.net/10356/103337
http://hdl.handle.net/10220/19283
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA- related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/ development.

Similar Items