MicroRNAs : the next generation therapeutic targets in human diseases

MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA- related genetic alter...

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Main Authors:	Srinivasan, Sakthivel, Selvan, Subramanian Tamil, Archunan, Govindaraju, Gulyas, Balazs, Padmanabhan, Parasuraman
Other Authors:	Lee Kong Chian School of Medicine (LKCMedicine)
Format:	Article
Language:	English
Published:	2014
Subjects:	DRNTU::Science::Medicine
Online Access:	https://hdl.handle.net/10356/103337 http://hdl.handle.net/10220/19283
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-103337
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spelling	sg-ntu-dr.10356-1033372022-02-16T16:30:15Z MicroRNAs : the next generation therapeutic targets in human diseases Srinivasan, Sakthivel Selvan, Subramanian Tamil Archunan, Govindaraju Gulyas, Balazs Padmanabhan, Parasuraman Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Science::Medicine MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA- related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/ development. Published version 2014-04-30T08:32:55Z 2019-12-06T21:10:24Z 2014-04-30T08:32:55Z 2019-12-06T21:10:24Z 2013 2013 Journal Article Srinivasan, S., Selvan, S. T., Archunan, G., Gulyas, B., & Padmanabhan, P. (2013). MicroRNAs -the Next Generation Therapeutic Targets in Human Diseases. Theranostics, 3(12), 930-942. 1838-7640 https://hdl.handle.net/10356/103337 http://hdl.handle.net/10220/19283 10.7150/thno.7026 24396504 en Theranostics © 2013 Ivyspring International Publishers. This paper was published in Theranostics and is made available as an electronic reprint (preprint) with permission of Ivyspring International Publishers. The paper can be found at the following official DOI: [http://dx.doi.org/10.7150/thno.7026]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 13 p. application/pdf
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	DRNTU::Science::Medicine
spellingShingle	DRNTU::Science::Medicine Srinivasan, Sakthivel Selvan, Subramanian Tamil Archunan, Govindaraju Gulyas, Balazs Padmanabhan, Parasuraman MicroRNAs : the next generation therapeutic targets in human diseases
description	MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA- related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/ development.
author2	Lee Kong Chian School of Medicine (LKCMedicine)
author_facet	Lee Kong Chian School of Medicine (LKCMedicine) Srinivasan, Sakthivel Selvan, Subramanian Tamil Archunan, Govindaraju Gulyas, Balazs Padmanabhan, Parasuraman
format	Article
author	Srinivasan, Sakthivel Selvan, Subramanian Tamil Archunan, Govindaraju Gulyas, Balazs Padmanabhan, Parasuraman
author_sort	Srinivasan, Sakthivel
title	MicroRNAs : the next generation therapeutic targets in human diseases
title_short	MicroRNAs : the next generation therapeutic targets in human diseases
title_full	MicroRNAs : the next generation therapeutic targets in human diseases
title_fullStr	MicroRNAs : the next generation therapeutic targets in human diseases
title_full_unstemmed	MicroRNAs : the next generation therapeutic targets in human diseases
title_sort	micrornas : the next generation therapeutic targets in human diseases
publishDate	2014
url	https://hdl.handle.net/10356/103337 http://hdl.handle.net/10220/19283
_version_	1725985566664687616

MicroRNAs : the next generation therapeutic targets in human diseases

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