Synthesis, Characterization, and Biological Properties of Osmium-Based Tamoxifen Derivatives - Comparison with Their Homologues in the Iron and Ruthenium Series

• Main Authors: Lee, Hui Zhi Shirley, Buriez, Olivier, Chau, François, Labbé, Eric, Ganguly, Rakesh, Amatore, Christian, Jaouen, Gérard, Vessières, Anne, Leong, Weng Kee, Top, Siden
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/103650; http://hdl.handle.net/10220/38791
• Institution: Nanyang Technological University

Three osmium analogues 3a–3c of hydroxytamoxifen were prepared. The antiproliferative effects of these complexes were measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and compared with those of their homologues of ferrocene (1a–1c) and ruthenocene (2a–2c). The tamoxifen-like comp...