A novel λ integrase-mediated seamless vector transgenesis platform for therapeutic protein expression

• المؤلفون الرئيسيون: Makhija, Harshyaa, Roy, Suki, Hoon, Shawn, Ghadessy, Farid John, Wong, Desmond, Jaiswal, Rahul, Campana, Dario, Dröge, Peter
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Transgenesis; Protein Expression; DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/103690; http://hdl.handle.net/10220/47376

Advances in stem cell engineering, gene therapy and molecular medicine often involve genome engineering at a cellular level. However, functionally large or multi transgene cassette insertion into the human genome still remains a challenge. Current practices such as random transgene integration or ta...