Young capillary vessels rejuvenate aged pancreatic islets

Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet fu...

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Main Authors: Almaça, Joana, Molina, Judith, Arrojo e Drigo, Rafael, Abdulreda, Midhat H., Jeon, Won Bae, Berggren, Per-Olof, Caicedo, Alejandro, Nam, Hong Gil
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2015
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Online Access:https://hdl.handle.net/10356/103728
http://hdl.handle.net/10220/24588
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-1037282022-02-16T16:28:42Z Young capillary vessels rejuvenate aged pancreatic islets Almaça, Joana Molina, Judith Arrojo e Drigo, Rafael Abdulreda, Midhat H. Jeon, Won Bae Berggren, Per-Olof Caicedo, Alejandro Nam, Hong Gil Lee Kong Chian School of Medicine (LKCMedicine) DRNTU::Science::Biological sciences Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet function are still disputed. Here we demonstrate that aging of pancreatic islets in mice and humans is notably associated with inflammation and fibrosis of islet blood vessels but does not affect glucose sensing and the insulin secretory capacity of islet beta cells. Accordingly, when transplanted into the anterior chamber of the eye of young mice with diabetes, islets from old mice are revascularized with healthy blood vessels, show strong islet cell proliferation, and fully restore control of glycemia. Our results indicate that beta cell function does not decline with age and suggest that islet function is threatened by an age-dependent impairment of islet vascular function. Strategies to mitigate age-dependent dysregulation in glycemia should therefore target systemic and/or local inflammation and fibrosis of the aged islet vasculature. Published version 2015-01-12T06:11:50Z 2019-12-06T21:18:58Z 2015-01-12T06:11:50Z 2019-12-06T21:18:58Z 2014 2014 Journal Article Almaça, J., Molina, J., Arrojo e Drigo, R., Abdulreda, M. H., Jeon, W. B., Berggren, P. O., et al. (2014). Young capillary vessels rejuvenate aged pancreatic islets. Proceedings of the National Academy of Sciences, 111(49), 17612-17617. 1091-6490 https://hdl.handle.net/10356/103728 http://hdl.handle.net/10220/24588 10.1073/pnas.1414053111 25404292 en Proceedings of the National Academy of Sciences © 2014 The Author(s). This paper was published in Proceedings of the National Academy of Sciences and is made available as an electronic reprint (preprint) with permission of the Author(s). The paper can be found at the following official DOI: [http://dx.doi.org/10.1073/pnas.1414053111].  One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 6 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Biological sciences
spellingShingle DRNTU::Science::Biological sciences
Almaça, Joana
Molina, Judith
Arrojo e Drigo, Rafael
Abdulreda, Midhat H.
Jeon, Won Bae
Berggren, Per-Olof
Caicedo, Alejandro
Nam, Hong Gil
Young capillary vessels rejuvenate aged pancreatic islets
description Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet function are still disputed. Here we demonstrate that aging of pancreatic islets in mice and humans is notably associated with inflammation and fibrosis of islet blood vessels but does not affect glucose sensing and the insulin secretory capacity of islet beta cells. Accordingly, when transplanted into the anterior chamber of the eye of young mice with diabetes, islets from old mice are revascularized with healthy blood vessels, show strong islet cell proliferation, and fully restore control of glycemia. Our results indicate that beta cell function does not decline with age and suggest that islet function is threatened by an age-dependent impairment of islet vascular function. Strategies to mitigate age-dependent dysregulation in glycemia should therefore target systemic and/or local inflammation and fibrosis of the aged islet vasculature.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Almaça, Joana
Molina, Judith
Arrojo e Drigo, Rafael
Abdulreda, Midhat H.
Jeon, Won Bae
Berggren, Per-Olof
Caicedo, Alejandro
Nam, Hong Gil
format Article
author Almaça, Joana
Molina, Judith
Arrojo e Drigo, Rafael
Abdulreda, Midhat H.
Jeon, Won Bae
Berggren, Per-Olof
Caicedo, Alejandro
Nam, Hong Gil
author_sort Almaça, Joana
title Young capillary vessels rejuvenate aged pancreatic islets
title_short Young capillary vessels rejuvenate aged pancreatic islets
title_full Young capillary vessels rejuvenate aged pancreatic islets
title_fullStr Young capillary vessels rejuvenate aged pancreatic islets
title_full_unstemmed Young capillary vessels rejuvenate aged pancreatic islets
title_sort young capillary vessels rejuvenate aged pancreatic islets
publishDate 2015
url https://hdl.handle.net/10356/103728
http://hdl.handle.net/10220/24588
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