The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain

The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor expressed in metazoan cells that is responsible for eliciting the production of type I interferons and pro-inflammatory cytokines upon detection of intracellular, non-self RNA. Structural studies of RIG-I have identified a nove...

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Bibliographic Details
Main Authors: Rawling, David C., Kohlway, Andrew S., Luo, Dahai, Ding, Steve C., Pyle, Anna Marie
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Medicine
Online Access:https://hdl.handle.net/10356/103799
http://hdl.handle.net/10220/24585
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/103799
http://hdl.handle.net/10220/24585

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