The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain
Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor expressed in metazoan cells that is responsible for eliciting the production of type I interferons and pro-inflammatory cytokines upon detection of intracellular, non-self RNA. Structural studies of RIG-I have identified a nove...
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| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/103799 http://hdl.handle.net/10220/24585 |
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| Institution: | Nanyang Technological University |
| Language: | English |