The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain

• Main Authors: Rawling, David C., Kohlway, Andrew S., Luo, Dahai, Ding, Steve C., Pyle, Anna Marie
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/103799; http://hdl.handle.net/10220/24585
• Institution: Nanyang Technological University

Retinoic acid-inducible gene I (RIG-I) is a pattern recognition receptor expressed in metazoan cells that is responsible for eliciting the production of type I interferons and pro-inflammatory cytokines upon detection of intracellular, non-self RNA. Structural studies of RIG-I have identified a nove...