Allosteric inhibition of the T cell receptor by a designed membrane ligand

Allosteric inhibition of the T cell receptor by a designed membrane ligand

The T cell receptor (TCR) is a complex molecular machine that directs the activation of T cells, allowing the immune system to fight pathogens and cancer cells. Despite decades of investigation, the molecular mechanism of TCR activation is still controversial. One of the leading activation hypothese...

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Bibliographic Details
Main Authors: Ye, Yujie, Morita, Shumpei, Chang, Justin J., Buckley, Patrick M., Wilhelm, Kiera B., DiMaio, Daniel, Groves, Jay T., Barrera, Francisco N.
Other Authors: Institute for Digital Molecular Analytics and Science (IDMxS)
Format: Article
Language:English
Published: 2024
Subjects:
Chemistry
Ligands
Phosphorylation
Online Access:https://hdl.handle.net/10356/173766
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/173766

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