Allosteric inhibition of the T cell receptor by a designed membrane ligand

• Main Authors: Ye, Yujie, Morita, Shumpei, Chang, Justin J., Buckley, Patrick M., Wilhelm, Kiera B., DiMaio, Daniel, Groves, Jay T., Barrera, Francisco N.
• Other Authors: Institute for Digital Molecular Analytics and Science (IDMxS)
• Format: Article
• Language: English
• Published: 2024
• Subjects: Chemistry; Ligands; Phosphorylation
• Online Access: https://hdl.handle.net/10356/173766
• Institution: Nanyang Technological University

The T cell receptor (TCR) is a complex molecular machine that directs the activation of T cells, allowing the immune system to fight pathogens and cancer cells. Despite decades of investigation, the molecular mechanism of TCR activation is still controversial. One of the leading activation hypothese...