Enhanced ex vivo expansion of adult mesenchymal stem cells by fetal mesenchymal stem cell ECM

• Main Authors: Chan, Jerry Kok Yen, Ng, Chee Ping, Mohamed Sharif, Abdul Rahim, Heath, Daniel E., Chow, John W., Zhang, Claire B. Y., Chan-Park, Mary B., Hammond, Paula T., Griffith, Linda G.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Chemical engineering::Biochemical engineering
• Online Access: https://hdl.handle.net/10356/103881; http://hdl.handle.net/10220/19361
• Institution: Nanyang Technological University

Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their quality/quantity declines with donor age and disease. Identification of cultur...